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Actual and potential Medical Uses of Cannabis

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Actual and potential Medical Uses of Cannabis Traditional Medicine Sedative, relaxant, anxiolytic (26) Analgesic Antidiarrheal (27) Anticonvulsant Antipyretic Antibiotic Appetite stimulant Treatment of
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Actual and potential Medical Uses of Cannabis Traditional Medicine Sedative, relaxant, anxiolytic (26) Analgesic Antidiarrheal (27) Anticonvulsant Antipyretic Antibiotic Appetite stimulant Treatment of withdrawal reactions (Alcohol, Opiates) Modern Medicine Accepted uses anti-nauseant, antiemetic (1-4) appetite stimulant (5-6) cancer chemotherapy (7-9), AIDS (10-12) Possible uses worth study/under investigations: analgesia (13-14) antispasticity (e.g. multiple sclerosis) (15-16) immunosuppressant/immunoregaltive (17-19) glaucoma (20-23) anticonvulsant, mainly cannabidiol (CBD), not THC (24-25) 3 Ps strategy in Medicine & Medicinal Cannabis Preventive/Predictive/Personalized - Preventive and Predictive Features of Medical cannabis: Endocannabinoid system (ECS) can be an indicator of our homeostatic status, one of the most crucial roles of Preventive and Predictive Medicine which is to help us maintain our internal balance. Any changes or alteration in ECS system - Personalized Feature of Medical cannabis: Medicinal Cannabis provides the patients with control over their treatments. The patients decide which strain of cannabis plant best suits their treatment goals and what dosing amount and schedule is most appropriate for them. This alone makes the experience more personal. Economic and financial Opportunity: Providing and maintaining the items above and establishing a system to serve the patients using or plan to use the medical cannabis can be a very good source of monetory factor which can eventually be one of the best source of financial aids for research, education and healthe care system improvement. **Specialised EPMA J. issue 2020 is in preparation Anti-Nauseant, Antiemetic 1. Todaro, B Cannabinoids in the treatment of chemotherapy-induced nausea and vomiting. Journal of the National Comprehensive Cancer Network 10(4): Smith, L. A., F. Azariah, T. C. V. Lavender, N. S. Stoner, and S. Bettiol Cannabinoids for nausea and vomiting in adults with cancer receiving chemotherapy. Cochrane Database of Systematic Reviews (11):CD Phillips, R. S., A. J. Friend, F. Gibson, E. Houghton, S. Gopaul, J. V. Craig, and B. Pizer Antiemetic medication for prevention and treatment of chemotherapy-induced nausea and vomiting in childhood. Cochrane Database of Systematic Reviews (2):CD Smith, L. A., F. Azariah, T. C. V. Lavender, N. S. Stoner, and S. Bettiol Cannabinoids for nausea and vomiting in adults with cancer receiving chemotherapy. Cochrane Database of Systematic Reviews (11):CD Appetite Stimulant 5. Foltin, R. W., M. W. Fischman, and M. F. Byrne Effects of smoked marijuana on food intake and body weight of humans living in a residential laboratory. Appetite 11(1): Di Marzo, V., F. Piscitelli, and R. Mechoulam Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes. Handbook of Experimental Pharmacology 203: Cancer 7. Simmerman E, Qin X, Yu JC, Baban B. Cannabinoids as a Potential New and Novel Treatment for Melanoma: A Pilot Study in a Murine Model. J Surg Res Mar;235: Abrams DI, Guzman M. Cannabis in cancer care. Clin Pharmacol Ther Jun;97(6): Sharafi G, He H, Nikfarjam M. Potential Use of Cannabinoids for the Treatment of Pancreatic Cancer. J Pancreat Cancer Jan 25;5(1):1-7. HIV/AIDS 10. Mannes ZL, Burrell LE, Ferguson EG, Zhou Z, Lu H, Somboonwit C6, Cook RL2,3, Ennis N1. The association of therapeutic versus recreational marijuana use and antiretroviral adherence among adults living with HIV in Florida. Patient Prefer Adherence Jul 27;12: Lee JT, Saag LA, Kipp AM, Logan J, Shepherd BE, Koethe JR, Turner M, Bebawy S, Sterling TR, Hulgan T. Selfreported Cannabis Use and Changes in Body Mass Index, CD4 T-Cell Counts, and HIV-1 RNA Suppression in Treated Persons with HIV. AIDS Behav Feb Kim PS, Fishman MA. Cannabis for Pain and Headaches: Primer. Curr Pain Headache Rep Apr;21(4):19. Analgesia 13. Khan SP, Pickens TA, Berlau DJ. Perspectives on cannabis as a substitute for opioid analgesics. Pain Manag Mar 1;9(2): Weizman L, Dayan L, Brill S, Nahman-Averbuch H, Hendler T, Jacob G, Sharon H. Cannabis analgesia in chronic neuropathic pain is associated with altered brain connectivity. Neurology Oct 2;91(14):e1285-e1294. Antispasticity (e.g. multiple sclerosis) 15. Koppel, B. S., J. C. Brust, T. Fife, J. Bronstein, S. Youssof, G. Gronseth, and D. Gloss Systematic review: Efficacy and safety of medical marijuana in selected neurologic disorders: Report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology 82(17): Whiting, P. F., R. F. Wolff, S. Deshpande, M. Di Nisio, S. Duffy, A. V. Hernandez, J. C. Keurentjes, S. Lang, K. Misso, S. Ryder, S. Schmidlkofer, M. Westwood, and J. Kleijnen Cannabinoids for medical use: A systematic review and meta-analysis. JAMA 313(24): Immunosuppressant/ immunoregaltive 17. Carrier, E. J., J. A. Auchampach, and C. J. Hillard Inhibition of an equilibrative nucleoside transporter by cannabidiol: A mechanism of cannabinoid immunosuppression. Proceedings of the National Academy of Sciences of the United States of America 103(20): Braun M, Khan ZT, Khan MB, Kumar M, Ward A, Achyut BR, Arbab AS, Hess DC, Hoda MN, Baban B, Dhandapani KM, Vaibhav K., Selective activation of cannabinoid receptor-2 reduces neuroinflammation after traumatic brain injury via alternative macrophage polarization., Brain Behav Immun Feb;68: Baban B, Hoda N, Malik A, Khodadadi H, Simmerman E, Vaibhav K, Mozaffari MS., Impact of cannabidiol treatment on regulatory T-17 cells and neutrophil polarization in acute kidney injury., Am J Physiol Renal Physiol Oct 1;315(4):F1149- F1158. Glaucoma 20. Whiting, P. F., R. F. Wolff, S. Deshpande, M. Di Nisio, S. Duffy, A. V. Hernandez, J. C. Keurentjes, S. Lang, K. Misso, S. Ryder, S. Schmidlkofer, M. Westwood, and J. Kleijnen Cannabinoids for medical use: A systematic review and meta-analysis. JAMA 313(24): Tomida, I., A. Azuara-Blanco, H. House, M. Flint, R. Pertwee, and P. Robson Effect of sublingual application of cannabinoids on intraocular pressure: A pilot study. Journal of Glaucoma 15(5): Prum, Jr., B. E., L. F. Rosenberg, S. J. Gedde, S. L. Mansberger, J. D. Stein, S. E. Moroi, L. W. 23. Herndon, Jr., M. C. Lim, and R. D. Williams Primary open-angle glaucoma Preferred Practice Pattern guidelines. Ophthalmology 123(1):P41 P111. Anticonvulsant 24. Russo, E. B History of cannabis and its preparations in saga, science, and sobriquet. Chemistry and Biodiversity 4(8): Reddy DS, Golub VM. The Pharmacological Basis of Cannabis Therapy for Epilepsy. J Pharmacol Exp Ther Apr;357(1):45-55. Sedative, relaxant, anxiolytic 26. Shen, M., and S. A. Thayer Cannabinoid receptor agonists protect cultured rat hippocampal neurons from excitotoxicity. Molecular Pharmacology 54: Antidiarrheal 27. Chaturvedi GN, Tiwari SK, Rai NP. Medicinal use of opium and cannabis in Medieval India. Indian J Hist Sci. 1981, reçu 1982;16(1):31-5.
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